Trinity College Dublin

Trinity College Dublin

Trinity College Dublin
College Green
2 Dublin
Ireland

www.tcd.ie

Project Coordinator

Prof. Brian Lawlor

Prof. Brian Lawlor
Phone: +353 1 249 3283
Fax: +353 1 677 5016

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Scientific Project Manager

Ms. Fiona Cregg

Fiona Cregg

Phone: +353 1 416 2082

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Research Assistant

Ms. Hannah McCarthy

Dr. Hannah McCarthy

Phone: +353 1 410 3863

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Project Staff

Dr. Cathal Walsh
Statistician

Dr. Sean Kennelly

Dr. Sean Kennelly
Medical Advisor

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Institute Presentation

Founded in 1592, Trinity College Dublin (TCD) is the leading academic institution in Ireland and is ranked 52nd inthe world league of 3rd level colleges. The university, through the Trinity College Institute of Neuroscience (TCIN)and its links with the Memory Clinic at St. James’s Hospital is a recognised centre of excellence in Ageing,Alzheimer’s disease and neuro-degeneration and is a member of the European Alzheimer’s Disease Consortium.Over the past 10 years, the ageing and dementia research programmes at TCD and its partner clinical site at St.James’s Hospital have attracted more than €130 million in research funding in areas such as epidemiology,neuropsychopharmacology, neurogenetics, and neuroimaging, experimental medicine and clinical trials.

Professor Lawlor trained in both internal medicine and psychiatry. He completed his MRCPI in Ireland before training in psychiatry in the USA, first as a resident in psychiatry at the University of Florida and then as a research fellow in neuropharmacology and Alzheimer’s disease at NIMH, Bethesda, Maryland. Before returning to Dublin in 1991, Professor Lawlor was Chief of Geriatric Psychiatry at Mount Sinai Hospital, New York.  Professor Lawlor’s research interests are in the early detection, diagnosis and treatment of Alzheimer's disease, the neurobiology and treatment of behavioural and psychological symptoms in dementia and mental disorders in the community dwelling elderly. Professor Lawlor has conducted longitudinal cohort studies of Alzheimer's disease in clinical settings and cross sectional and longitudinal studies of community dwelling healthy older people and those with mental disorders. The overarching aims of Professor Lawlor’s research programmes are to develop clinical, neuropsychological and biological markers of Alzheimer's disease at the earliest possible stage and to test promising new interventions in clinical populations.

Professor Lawlor’s research is carried out in partnership with disciplines from basic science, ranging from development of animal models of Alzheimer's disease to health service development, clinical trials and implementation. Professor Lawlor is currently participating in a number of collaborative studies, including BIOMARKAPD, a JPND initiative aimed at Alzheimer’s disease biomarker optimisation and standardisation across Europe, the GSK Translational Research in Alzheimer's Disease study which aims to develop markers of Alzheimer’s disease using combined ERP/fMRI to assess response to short term doses of donepezil and a longitudinal study to increase understanding of the neurocardiovascular contribution to the transition from mild cognitive impairment to dementia. Professor Lawlor was lead PI in the I/IIa trial carried out in collaboration with the Roskamp Institute, Florida, and Trinity College Institute of Neurosciences, examining the safety and efficacy of Nilvadapine treatment.

Professor Lawlor has a particular interest in improvement of mental health outcomes in the elderly and is lead PI of the Social Connection Strand of Technology Research in Independent Living, examining social engagement, loneliness and related mental health issues and how technology might be of benefit.  He is also lead PI of the Enhancing Care in Alzheimer’s Disease (ECAD) study, a long term study exploring the economic, psychological and physical impact of Alzheimer’s disease for patients and caregivers and is conducting an RCT examining the benefit of a volunteer intervention in older people who are lonely.  

Professor Lawlor has published over 200 papers in his research field and has edited three books on Old Age Psychiatry.

Dr. Sean Kennelly MB BCh PhD Dip stroke MRCPI
Dr. Kennelly was appointed as medical scientific advisor with the Trinity College Dublin NILVAD partners in January 2013. Dr. Kennelly is a consultant physician in geriatric medicine in the Adelaide and Meath hospital, Tallaght in Dublin. He is clinical senior lecturer in medical gerontology in TCD. Following graduation from Trinity College Dublin in 2001, he completed the majority of his training in geriatric medicine in St. James and Tallaght hospital in Dublin. As part of his TCD doctoral thesis Dr. Kennelly conducted the first substantive study investigating the safety and efficacy of nilvadipine in AD patients. He is one of the principle investigators on the first Irish National Audit of Dementia (INAD) care in acute general hospitals. He is a founder member of the Irish Society of Acute Medicine and the Irish Delirium Society. He is a member of the specialist training committee for internal and acute medicine in the Royal College of Physicians in Ireland.

His primary research interests include Alzheimer's disease and other dementia subtypes, delirium, acute geriatric medicine, and residential and rehabilitation care medicine.

 

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